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| Reactivity: | H,M,R |
| Applications: | WB |
| Host Species: | Rabbit |
| Clonality: | Polyclonal |
| Full Name: | ATIC rabbit polyclonal antibody |
Gene Name: | Bifunctional purine biosynthesis protein PURH |
Synonyms: | Phosphoribosylaminoimidazolecarboxamide formyltransferase, AICAR transformylase, Atic, Purh, 5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase, Inosinicase |
Immunogen: | Recombinant protein corresponding to Mouse ATIC |
Isotype: | IgG |
Purity: | Affinity purification |
Predicted MW. | 64 kDa |
Observed MW. | 64 kDa |
Uniprot ID: | P31939, Q9CWJ9, O35567 |
Product Usage Information
Applications | Species | Dilution | Positive tissue |
WB | Human, Mouse, Rat | 1: 500-1: 1000 | HeLa, HepG2, NIH/3T3, PC-12, Jurkat |
Background
The bifunctional purine biosynthesis protein ATIC (also designated PURH) contains AICAR transformylase and IMP cyclohydrolase activities. AICAR (5-aminoimidazole-4-carboxamide ribonucleotide) transformylase catalyzes the second to last step in purine biosynthesis, playing an important role in the production of nucleotides and IMP. Defects in the ATIC transformylase gene can cause AICA-rebsuria, also designated AICA-ribosiduria, an inborn error in purine biosynthes is that is neurologically cataclysmic. Individuals with AICA-rebosuria accumulate AICA-riboside, also designated ZMP, and its derivatives in erythrocytes and fibroblasts. Patients also excrete very large amounts of AICA-riboside in the urine. Mental retardation, epilepsy, dysmorphic features and congenital blindness are all symptoms of this disease.
Images
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Western blot analysis of IMP synthase (GB11975) at dilution of 1: 500 |
Storage
| Storage | Store at -20°C for one year. Avoid repeated freeze/ thaw cycles. |
| Storage Buffer | PBS with 0.02% sodium azide, 100 μg/ml BSA and 50% glycerol. |
