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Anti-ATP citrate lyase Rabbit pAb (100 μl)
| Reactivity: | H,M,R |
| Applications: | WB |
| Host Species: | Rabbit |
| Clonality: | Polyclonal |
| Full Name: | ATP citrate lyase rabbit polyclonal antibody |
Gene Name: | ATP-citrate synthase |
Synonyms: | Acly, ACL, ATP citrate lyase, ATP citrate synthase, ATPCL, Citrate cleavage enzyme, CLATP, ATP-citrate (pro-S-)-lyase |
Immunogen: | Recombinant protein corresponding to Mouse ATP citrate lyase |
Isotype: | IgG |
Purity: | Affinity purification |
Predicted MW. | 120 kDa |
Observed MW. | 120 kDa |
Uniprot ID: |
Product Usage Information
Applications | Species | Dilution | Positive tissue |
WB | Human, Mouse, Rat | 1: 500-1: 1000 | cerebral cortex, fat, brain |
Background
ATP citrate lyase is the primary enzyme responsible for the synthesis of cytosolic acetyl-CoA in many tissues. The enzyme is a tetramer (relative molecular weight approximately 440,000) of apparently identical subunits. It catalyzes the formation of acetyl-CoA and oxaloacetate from citrate and CoA with a concomitant hydrolysis of ATP to ADP and phosphate. The product, acetyl-CoA, serves several important biosynthetic pathways, including lipogenesis and cholesterogenesis. In nervous tissue, ATP citrate-lyase may be involved in the biosynthesis of acetylcholine. Two transcript variants encoding distinct isoforms have been identified for this gene.
Images
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Western blot analysis of Atpcitratelyase (GB11902) at dilution of 1: 500 |
Storage
| Storage | Store at -20°C for one year. Avoid repeated freeze/ thaw cycles. |
| Storage Buffer | PBS with 0.02% sodium azide, 100 μg/ml BSA and 50% glycerol. |
