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Anti-Acidic Cytokeratin Mouse mAb (100 μl)
| Reactivity: | H |
| Applications: | IHC/IF |
| Host Species: | Mouse |
| Clonality: | Monoclonal |
| Gene Name: | Acidic Cytokeratin |
Synonyms: | Cytokeratin-20 (CK-20), Keratin-20 (K20), Protein IT |
Immunogen: | KLH conjugated Synthetic peptide corresponding to Human CK20 |
Uniprot ID: | P35900 |
Isotype: | IgG2a,κ |
Purity: | Affinity purification |
Subcellular location: | Nucleus, Secreted, Cytoplasm |
Product Usage Information
Applications | Species | Dilution | Positive Sample |
IHC/IF | Human | 1: 500-1: 1000 | esophageal squamous cell carcinoma, lung adenocarcinoma, lung squamous cell carcinoma |
Background
Keratins are a large family of proteins that form the intermediate filament cytoskeleton of epithelial cells, which are classified into two major sequence types. Type I keratins are a group of acidic intermediate filament proteins, including K9-K23, and the hair keratins Ha1-Ha8. Type II keratins are the basic or neutral courterparts to the acidic type I keratins, including K1-K8, and the hair keratins, Hb1-Hb6. Keratin 20 is a type I cytokeratin. It is a major cellular protein of mature enterocytes and goblet cells and is specifically found in the gastric and intestinal mucosa.
Images
 | Immunohistochemistry analysis of paraffin embedded human esophageal squamous cell carcinoma using Acidic Cytokeratin (GB122051) at dilution of 1: 1000 |
 | Immunohistochemistry analysis of paraffin embedded human lung adenocarcinoma using Acidic Cytokeratin (GB122051) at dilution of 1: 1000 |
 | Immunohistochemistry analysis of paraffin embedded human lung squamous cell carcinoma using Acidic Cytokeratin (GB122051) at dilution of 1: 1000 |
Storage
| Storage | Store at -20°C for one year. Avoid repeated freeze/thaw cycles. |
| Storage Buffer | PBS with 0.02%sodium azide,100 μg/ml BSA and 50% glycerol. |