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Anti-Activin Receptor Type IA Rabbit pAb (100 μl)
| Reactivity: | M,R & M,R & M,R |
| Applications: | WB & IHC/IF & IEM |
| Host Species: | Rabbit |
| Clonality: | Polyclonal |
| Gene Name: | Activin receptor type-1 |
Synonyms: | Activin A receptor type I, Activin A receptor type II like kinase 2, Activin receptor type-1, Activin receptor-like kinase 2, ACTR-I, ACTRI, Acvr1, ACVRLK2, FOP, TSRI, SKR1, ALK2, Hydroxyalkyl protein kinase |
Immunogen: | KLH conjugated Synthetic peptide corresponding to Mouse Activin Receptor Type IA |
Uniprot ID: | P37172 |
Isotype: | lgG |
Purity: | Affinity purification |
Predicted MW. / Observed MW. | 57 kDa / 57 kDa |
Product Usage Information
WB | Mouse, Rat | 1: 300-1: 500 | brain |
Background
Bone morphogenetic protein (BMP) type I receptor that is involved in a wide variety of biological processes, including bone, heart, cartilage, nervous, and reproductive system development and regulation As a type I receptor, forms heterotetrameric receptor complexes with the type II receptors AMHR2, ACVR2A ors ACVR2B. Upon binding of ligands such as BMP7 or BMP9 to the heteromeric complexes, type II receptors transphosphorylate ACVR1 intracellular domain. In turn, ACVR1 kinase domain is activated and subsequently phosphorylates SMAD1/5/8 proteins that transduce the signal. In addition to its role in mediating BMP pathway-specific signaling, suppresses TGFbeta/activin pathway signaling by interfering with the binding of activin to its type II receptor.
Images
| WB analysis of ActivinRtype1 (GB115550). |
Storage
| Storage | Store at -20°C for one year. Avoid repeated freeze/thaw cycles. |
| Storage Buffer | PBS with 0.02%sodium azide,100 μg/ml BSA and 50% glycerol. |
