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Anti-Aldolase Rabbit pAb (100 μl)
| Reactivity: | M,R |
| Applications: | WB |
| Host Species: | Rabbit |
| Clonality: | Polyclonal |
| Full Name: | Aldolase rabbit polyclonal antibody |
Gene Name: | Fructose-bisphosphate aldolase A |
Synonyms: | Aldolase 1, Muscle-type aldolase, Aldoa, Aldo1, Aldolase A, Fructose 1 6 bisphosphate triosephosphate lyase, GSD12, Lung cancer antigen NY LU 1 |
Immunogen: | KLH conjugated Synthetic peptide corresponding to Mouse Aldolase |
Isotype: | IgG |
Purity: | Affinity purification |
Predicted MW. | 39 kDa |
Observed MW. | 39 kDa |
Uniprot ID: | P05064, P05065 |
Product Usage Information
Applications | Species | Dilution | Positive tissue |
WB | Mouse, Rat | 1: 500-1: 1000 | skeletal muscle, brain, heart |
Background
Aldolase A (fructose bisphosphate aldolase) is a glycolytic enzyme that catalyzes the reversible conversion of fructose-1,6-bisphosphate to glyceraldehyde 3 phosphate and dihydroxyacetone phosphate. Three aldolase isozymes (A, B, and C), encoded by three different genes, are differentially expressed during development. Aldolase A is found in the developing embryo and is produced in even greater amounts in adult muscle. Aldolase A expression is repressed in adult liver, kidney and intestine and similar to aldolase C levels in brain and other nervous tissue. Research studies suggest that Aldolase A is upregulated in various cancers, including human lung squamous and renal cell carcinomas. Aldolase A deficiency has been associated with myopathy and hemolytic anemia. Alternative splicing of this gene results in multiple transcript variants which encode the same protein.
Images
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Western blot analysis of ALDA (GB11956) at dilution of 1: 500 |
Storage
| Storage | Store at -20°C for one year. Avoid repeated freeze/ thaw cycles. |
| Storage Buffer | PBS with 0.02% sodium azide, 100 μg/ml BSA and 50% glycerol. |