Reactivity: | M,R |
Applications: | WB |
Host Species: | Rabbit |
Clonality: | Polyclonal |
Full Name: | BMP2 rabbit polyclonal antibody |
Gene Name: | Bone morphogenetic protein 2 |
Synonyms: | BMP2, BDA2, BMP2A, bone morphogenetic protein 2 |
Immunogen: | KLH conjugated Synthetic peptide corresponding to Mouse BMP2 |
Isotype: | IgG |
Purity: | Affinity purification |
Subcellular location: | Secreted |
Predicted MW. | 45 kDa |
Observed MW. | 45 kDa |
Uniprot ID: | P12643, P21274, P49001 |
Product Usage Information
WB | Human, Mouse, Rat | 1: 500-1: 1000 | liver, spleen, lung |
IHC/IF | Human (predicted), Mouse, Rat | 1: 200-1: 1000 | bone |
Background
Induces cartilage and bone formation. Stimulates the differentiation of myoblasts into osteoblasts via the EIF2AK3-EIF2A- ATF4 pathway. BMP2 activation of EIF2AK3 stimulates phosphorylation of EIF2A which leads to increased expression of ATF4 which plays a central role in osteoblast differentiation. In addition stimulates TMEM119, which upregulates the expression of ATF4.
Images
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WB analysis of BMP2 (GB11252). |
IHC analysis of BMP2 (GB11252). |
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IHC analysis of BMP2 (GB11252). |
Storage
Storage | Store at -20°C for one year. Avoid repeated freeze/ thaw cycles. |
Storage Buffer | PBS with 0.02% sodium azide, 100 μg/ml BSA and 50% glycerol. |