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Anti-BPTF / FALZ Rabbit pAb (100 μl)
| Reactivity: | H,M,R |
| Applications: | IHC/IF |
| Host Species: | Rabbit |
| Clonality: | Polyclonal |
| Full Name: | BPTF rabbit polyclonal antibody |
Gene Name: | Nucleosome-remodeling factor subunit BPTF |
Synonyms: | Bromodomain and PHD finger-containing transcription factor, Fetal Alz-50 clone 1 protein, Fetal Alzheimer antigen, BPTF, FAC1, FALZ |
Immunogen: | Recombinant protein corresponding to Human BPTF |
Isotype: | IgG |
Purity: | Affinity purification |
Subcellular location: | Nucleus, Cytoplasm |
Uniprot ID: | Q12830 |
Product Usage Information
Applications | Species | Dilution | Positive tissue |
IHC/IF | Human, Mouse, Rat | 1:500-1:1000 | brain, colon cancer, liver, testis |
Background
FALZ/BPTF is a histone-binding component of NURF (nucleosome remodeling factor), a complex that catalyzes ATP-dependent nucleosome sliding and facilitates transcription of chromatin. This gene was identified in brain homogenates from patients with Alzheimer's disease. Analysis of the original protein (fetal Alz-50 reactive clone 1, or FAC1), containing a DNA-binding domain, a zinc finger motif, and a C-terminal bromodomain, suggested it might play a role in the regulation of transcription during proliferation. High levels of FAC1 were detected in fetal brain and in patients with neurodegenerative diseases. This protein is highly similar to the largest subunit of the Drosophila NURF (nucleosome remodeling factor) complex. In Drosophila, the NURF complex, which catalyzes nucleosome sliding on DNA and interacts with sequence-specific transcription factors, is necessary for the chromatin remodeling required for transcription.
Images
| Immunohistochemistry of paraffin embedded human colon cancer using BPTF (GB111201) at dilution of 1:500 (400x lens) |
| Immunohistochemistry of paraffin embedded mouse brain using BPTF (GB111201) at dilution of 1:500 (400x lens) |
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Immunohistochemistry of paraffin embedded mouse testis using BPTF (GB111201) at dilution of 1:1000 (400x lens) |
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Immunohistochemistry of paraffin embedded rat brain using BPTF (GB111201) at dilution of 1:500 (400x lens) |
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Immunohistochemistry of paraffin embedded rat liver using BPTF (GB111201) at dilution of 1:500 (400x lens) |
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Immunohistochemistry of paraffin embedded rat testis using BPTF (GB111201) at dilution of 1:1000 (400x lens) |
Storage
| Storage | Store at -20°C for one year. Avoid repeated freeze/ thaw cycles. |
| Storage Buffer | PBS with 0.02% sodium azide, 100 μg/ml BSA and 50% glycerol. |
