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Anti-CCDC22/JM1 Rabbit pAb (100 μl)
| Reactivity: | R |
| Applications: | WB |
| Host Species: | Rabbit |
| Clonality: | Polyclonal |
| Gene Name: | Coiled-coil domain-containing protein 22 |
Synonyms: | CCDC22, CXorf37, JM1 |
Immunogen: | KLH conjugated Synthetic peptide corresponding to Mouse CCDC22 |
Uniprot ID: | Q9JIG7 |
Isotype: | IgG |
Purity: | Affinity purification |
Predicted MW. / Observed MW. | 71 kDa / 71 kDa |
Product Usage Information
WB | Rat | 1: 1500-1: 3000 | pancreas , colon |
Background
Involved in regulation of NF-kappa-B signaling. Promotes ubiquitination of I-kappa-B-kinase subunit IKBKB and its subsequent proteasomal degradation leading to NF-kappa-B activation; the function may involve association with COMMD8 and a CUL1-dependent E3 ubiquitin ligase complex. May down-regulate NF-kappa-B activity via association with COMMD1 and involving a CUL2-dependent E3 ubiquitin ligase complex. Regulates the cellular localization of COMM domain-containing proteins, such as COMMD1 and COMMD10. Component of the CCC complex, which is involved in the regulation of endosomal recycling of surface proteins, including integrins, signaling receptor and channels.
Images
| Western blot analysis of CCDC22 (GB115169) at dilution of 1: 1500 |
Storage
| Storage | Store at -20°C for one year. Avoid repeated freeze/thaw cycles. |
| Storage Buffer | PBS with 0.02%sodium azide,100 μg/ml BSA and 50% glycerol. |
