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| Reactivity: | R |
| Applications: | IHC/IF |
| Host Species: | Mouse |
| Clonality: | Monoclonal |
| Gene Name: | Prominin-1 |
Synonyms: | PROM1, AC133, CD133, CORD12, MCDR2, MSTP061, PROML1, RP41, STGD4, prominin 1 |
Immunogen: | KLH conjugated Synthetic peptide corresponding to Mouse CD133 |
Uniprot ID: | O54990 |
Isotype: | IgG1,κ |
Purity: | Affinity purification |
Subcellular location: | Apical cell membrane,Cell projection,Endoplasmic reticulum |
Product Usage Information
IHC/IF | Rat | 1: 200-1: 800 | fetal rat |
Background
May play a role in cell differentiation, proliferation and apoptosis . Binds cholesterol in cholesterol-containing plasma membrane microdomains and may play a role in the organization of the apical plasma membrane in epithelial cells. During early retinal development acts as a key regulator of disk morphogenesis. Involved in regulation of MAPK and Akt signaling pathways. In neuroblastoma cells suppresses cell differentiation such as neurite outgrowth in a RET-dependent manner.
Images
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Immunohistochemistry analysis of paraffin-embedded fetal rat using CD133 (GB12060) at dilution of 1:400 |
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Immunohistochemistry analysis of paraffin-embedded fetal rat using CD133 (GB12060) at dilution of 1:400 |
Storage
| Storage | Store at -20°C for one year. Avoid repeated freeze/ thaw cycles. |
| Storage Buffer | PBS with 0.02% sodium azide, 100 μg/ml BSA and 50% glycerol. |
