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| Reactivity: | H |
| Applications: | WB |
| Host Species: | Rabbit |
| Clonality: | Polyclonal |
| Gene Name: | CD177 antigen |
Synonyms: | CD177, HNA-2a, HNA2A, NB1, NB1 GP, PRV-1, PRV1, CD177 molecule |
Immunogen: | KLH conjugated Synthetic peptide corresponding to Mouse CD177 |
Uniprot ID: | Q8R2S8 |
Isotype: | IgG |
Purity: | Affinity purification |
Subcellular location: | Cell membrane |
Predicted MW. / Observed MW. | 87 kDa / 105 kDa |
Product Usage Information
Applications | Species | Dilution | Positive Sample |
WB | Mouse | 1: 500-1: 1000 | lung, spleen, colon |
IHC/IF | Mouse, Rat | 1: 500-1: 2000 | bone, nephritis, pneumonia |
Background
This gene encodes a glycosyl-phosphatidylinositol (GPI)-linked cell surface glycoprotein that plays a role in neutrophil activation. The protein can bind platelet endothelial cell adhesion molecule-1 and function in neutrophil transmigration. Mutations in this gene are associated with myeloproliferative diseases. Over-expression of this gene has been found in patients with polycythemia rubra vera. Autoantibodies against the protein may result in pulmonary transfusion reactions, and it may be involved in Wegener's granulomatosis.
Images
| Western blot analysis of CD177 (GB11316) at dilution of 1: 1000 |
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Immunohistochemistry of paraffin embedded mouse spleen using CD177 (GB11316) at dilution of 1:1000 (400x lens) |
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Immunohistochemistry of paraffin embedded rat spleen using CD177 (GB11316) at dilution of 1:1000 (400x lens) |
| Immunohistochemistry of paraffin embedded rat thymus using CD177 (GB11316) at dilution of 1:1000 (400x lens) |
| Immunofluorescence of paraffin embedded mouse bone using CD177 (GB11316) at dilution of 1:500 (400x lens) |
| Immunofluorescence of paraffin embedded mouse nephritis using CD177 (GB11316) at dilution of 1:500 (400x lens) |
| Immunofluorescence of paraffin embedded rat pneumonia using CD177 (GB11316) at dilution of 1:500 (400x lens) |
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Immunofluorescence of paraffin embedded rat spleen using CD177 (GB11316) at dilution of 1:500 (400x lens) |
Storage
| Storage | Store at -20°C for one year. Avoid repeated freeze/ thaw cycles. |
| Storage Buffer | PBS with 0.02% sodium azide, 100 μg/ml BSA and 50% glycerol. |
