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Recombinant Anti-CD19 Rabbit mAb (100 μl)
| Reactivity: | H & H |
| Applications: | WB & IHC/IF |
| Host Species: | Rabbit |
| Clonality: | Monoclonal |
| Gene Name: | B-lymphocyte antigen CD19 |
Synonyms: | B lymphocyte antigen CD19, B4, CD19, CD19 molecule, Differentiation antigen CD19, T cell surface antigen Leu 12 |
Immunogen: | Human recombinant CD19 protein expressed in HEK293 cells |
Uniprot ID: | P15391 |
Isotype: | IgG |
Purity: | Affinity purification |
Subcellular location: | Cell membrane |
Predicted MW. / Observed MW. | 60 kDa / 90-120 kDa |
Product Usage Information
WB | Human | 1: 500-1: 1000 | Raji, Daudi, NALM-6 |
IHC/IF | Human | 1: 500-1: 2000 | tonsil |
Background
Functions as coreceptor for the B-cell antigen receptor complex (BCR) on B-lymphocytes. Decreases the threshold for activation of downstream signaling pathways and for triggering B-cell responses to antigens. Activates signaling pathways that lead to the activation of phosphatidylinositol 3-kinase and the mobilization of intracellular Ca(2+) stores. Is not required for early steps during B cell differentiation in the blood marrow. Required for normal differentiation of B-1 cells (By similarity). Required for normal B cell differentiation and proliferation in response to antigen challenges.
Images
| WB analysis of CD19(GB15006). |
| IHC analysis of CD19(GB15006). |
Storage
| Storage | Store at -20°C for one year. Avoid repeated freeze/thaw cycles. |
| Storage Buffer | PBS with 0.02%sodium azide,100 μg/ml BSA and 50% glycerol. |
