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Anti-CDKN2A/p19ARF Rabbit pAb (100 μl)
| Reactivity: | M,R |
| Applications: | WB |
| Host Species: | Rabbit |
| Clonality: | Polyclonal |
| Full Name: | CDKN2A/p19ARF rabbit polyclonal antibody |
Gene Name: | Cyclin-dependent kinase inhibitor 2A |
Synonyms: | Cdkn2a, CDKN2A, ARF, CDK4I, CDKN2, CMM2, INK4, INK4A, MLM, MTS-1, MTS1, P14, P14ARF, P16, P16-INK4A, P16INK4, P16INK4A, P19, P19ARF, TP16, Cyclin-dependent kinase inhibitor 2A, Cyclin dependent kinase inhibitor 2A |
Immunogen: | KLH conjugated Synthetic peptide corresponding to Mouse p19ARF |
Isotype: | IgG |
Purity: | Affinity purification |
Predicted MW. | 19 kDa |
Observed MW. | 20 kDa |
Uniprot ID: | Q64364, Q8QZZ9 |
Product Usage Information
Applications | Species | Dilution | Positive tissue |
WB | Mouse, Rat | 1: 500-1: 1000 | liver, brain |
Background
P19ARF Capable of inducing cell cycle arrest in G1 and G2 phases. Acts as a tumor suppressor. Binds to MDM2 and blocks its nucleocytoplasmic shuttling by sequestering it in the nucleolus. This inhibits the oncogenic action of MDM2 by blocking MDM2-induced degradation of p53 and enhancing p53-dependent transactivation and apoptosis. Also induces G2 arrest and apoptosis in a p53-independent manner by preventing the activation of cyclin B1/CDC2 complexes. Binds to BCL6 and down-regulates BCL6-induced transcriptional repression.
Images
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Western blot analysis of CDKN2A (GB11703) at dilution of 1: 500 |
Storage
| Storage | Store at -20°C for one year. Avoid repeated freeze/ thaw cycles. |
| Storage Buffer | PBS with 0.02% sodium azide, 100 μg/ml BSA and 50% glycerol. |
