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| Reactivity: | H & H,M,R |
| Applications: | WB & IHC/IF |
| Host Species: | Mouse |
| Clonality: | Monoclonal |
| Gene Name: | Homeobox protein CDX-2 |
Synonyms: | caudal type homeobox 2, Caudal type homeobox protein 2, CDX-3, CDX2, CDX-2, CDX3 |
Immunogen: | KLH conjugated Synthetic peptide corresponding to Human CDX2 |
Uniprot ID: | Q99626 |
Isotype: | IgG2a,κ |
Purity: | Affinity purification |
Subcellular location: | Nucleus |
Predicted MW. / Observed MW. | 34 kDa / 38 kDa |
Product Usage Information
WB | Human | 1: 500-1: 1000 | 293T, Caco-2 |
IHC/IF | Human, Mouse, Rat | 1: 1000-1: 3000 | colon cancer, colon, gastric carcinoma, small intestine |
Background
CDX2, also named as Homeobox protein CDX-2, is a 313 amino acid protein, which contains one homeobox DNA-binding domain and belongs to the Caudal homeobox family. CDX2 localizes in the nucleus and is involved in the transcriptional regulation of multiple genes expression in the intestinal epithelium. The relative expression of CDX1 to CDX2 protein may be important in the anterior to posterior patterning of the intestinal epithelium and in defining patterns of proliferation and differentiation along the crypt-villus axis.
Images
| Western blot analysis of CDX2 (GB121501) at dilution of 1: 1000 |
| Immunohistochemistry analysis of paraffin embedded human colon cancer using CDX2 (GB121501) at dilution of 1: 1000 |
| Immunohistochemistry analysis of paraffin embedded human colon using CDX2 (GB121501) at dilution of 1: 1000 |
| Immunohistochemistry analysis of paraffin embedded human gastric carcinoma using CDX2 (GB121501) at dilution of 1: 1000 |
| Immunohistochemistry analysis of paraffin embedded mouse colon using CDX2 (GB121501) at dilution of 1: 3000 |
| Immunohistochemistry analysis of paraffin embedded rat small intestine using CDX2 (GB121501) at dilution of 1: 1000 |
| Immunohistochemistry analysis of paraffin embedded human colon cancer using CDX2 (GB121501) at dilution of 1: 1000 |
Storage
| Storage | Store at -20°C for one year. Avoid repeated freeze/thaw cycles. |
| Storage Buffer | PBS with 0.02%sodium azide,100 μg/ml BSA and 50% glycerol. |
