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Anti-CELSR2 Rabbit pAb (100 μl)
| Reactivity: | H,M |
| Applications: | WB |
| Host Species: | Rabbit |
| Clonality: | Polyclonal |
| Full Name: | CELSR2 rabbit polyclonal |
Gene Name: | Cadherin EGF LAG seven-pass G-type receptor 2 |
Synonyms: | Flamingo homolog, Celsr2, Multiple epidermal growth factor-like domains protein 3, MEGF3, EGFL2, CDHF10 |
Immunogen: | KLH conjugated Synthetic peptide corresponding to Mouse CELSR2 |
Isotype: | IgG |
Purity: | Affinity purification |
Subcellular location: | |
Uniprot ID: |
Product Usage Information
Applications | Species | Dilution | Positive tissue |
IHC | Mouse, Rat | 1: 600-1: 1200 | lung, substantia nigra, spinal cord, eyeball, striatum |
IF | Mouse, Rat | 1: 300-1: 600 | lung, eyeball, spinal cord, brain, spleen |
Background
Drosophila Flamingo is a seven pass transmembrane cadherin that is necessary for dendritic patterning and axon guidance. Flamingo mammalian homo-logs play similar roles in neuronal development, during which they play an important role in cell-cell signaling. Cadherin EGF LAG seven pass G-type receptors (CELSRs) are multi-pass membrane proteins that belong to the G protein-coupled receptor family of proteins. Silencing CELSR2 gene ex-pression results in signficant simplification of dendritic arbors of cortical pyramidal neurons and Purkinje neurons, which may be due to branch retraction.
Images
| Immunohistochemistry analysis of paraffin-embedded mouse lung using CELSR2 (GB112930) at dilution of 1: 1200 |
| Immunohistochemistry analysis of paraffin-embedded rat lung using CELSR2 (GB112930) at dilution of 1: 1200 |
| Immunohistochemistry analysis of paraffin-embedded mouse substantia nigra using CELSR2 (GB112930) at dilution of 1: 1200 |
| Immunohistochemistry analysis of paraffin-embedded rat spinal cord using CELSR2 (GB112930) at dilution of 1: 1200 |
| Immunohistochemistry analysis of paraffin-embedded rat spinal cord using CELSR2 (GB112930) at dilution of 1: 1200 |
| Immunohistochemistry analysis of paraffin-embedded mouse eyeball using CELSR2 (GB112930) at dilution of 1: 1200 |
| Immunohistochemistry analysis of paraffin-embedded rat striatum using CELSR2 (GB112930) at dilution of 1: 1200 |
| Immunofluorescent analysis of paraformaldehyde-fixed mouse lung using CELSR2 (GB112930) at dilution of 1: 600 |
| Immunofluorescent analysis of paraformaldehyde-fixed mouse eyeball using CELSR2 (GB112930) at dilution of 1: 600 |
| Immunofluorescent analysis of paraformaldehyde-fixed rat spinal cord using CELSR2 (GB112930) at dilution of 1: 600 |
| Immunofluorescent analysis of paraformaldehyde-fixed rat brain using CELSR2 (GB112930) at dilution of 1: 600 |
| Immunofluorescent analysis of paraformaldehyde-fixed rat spleen using CELSR2 (GB112930) at dilution of 1: 600 |
Storage
| Storage | Store at -20°C for one year. Avoid repeated freeze/thaw cycles. |
| Storage Buffer | PBS with 0.02%sodium azide,100 μg/ml BSA and 50% glycerol. |
