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Anti-CENPE Rabbit pAb (100 μl)
| Reactivity: | M,R |
| Applications: | WB |
| Host Species: | Rabbit |
| Clonality: | Polyclonal |
| Gene Name: | Centromere-associated protein E |
Synonyms: | CENP E, Centromere protein E, centromere protein E, 312kDa, KIF10, Kinesin related protein CENPE |
Immunogen: | KLH conjugated Synthetic peptide corresponding to Human CENPE |
Uniprot ID: | Q02224 |
Isotype: | IgG |
Purity: | Affinity purification |
Predicted MW. / Observed MW. | 316 kDa / 310 kDa |
Product Usage Information
WB | Mouse, Rat | 1: 100-1: 300 | hippocampus, kidney |
Background
Microtubule plus-end-directed kinetochore motor which plays an important role in chromosome congression, microtubule-kinetochore conjugation and spindle assembly checkpoint activation. Drives chromosome congression (alignment of chromosomes at the spindle equator resulting in the formation of the metaphase plate) by mediating the lateral sliding of polar chromosomes along spindle microtubules towards the spindle equator and by aiding the establishment and maintenance of connections between kinetochores and spindle microtubules. The transport of pole-proximal chromosomes towards the spindle equator is favored by microtubule tracks that are detyrosinated. Acts as a processive bi-directional tracker of dynamic microtubule tips; after chromosomes have congressed, continues to play an active role at kinetochores, enhancing their links with dynamic microtubule ends.
Images
| Western blot analysis of CENPE (GB114962) at dilution of 1: 300 |
Storage
| Storage | Store at -20°C for one year. Avoid repeated freeze/thaw cycles. |
| Storage Buffer | PBS with 0.02%sodium azide,100 μg/ml BSA and 50% glycerol. |
