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Anti-CIB1/KIP Rabbit pAb (100 μl)
| Reactivity: | H,M,R |
| Applications: | WB |
| Host Species: | Rabbit |
| Clonality: | Polyclonal |
| Full Name: | CIB1 rabbit polyclonal antibody |
Gene Name: | Calcium and integrin-binding protein 1 |
Synonyms: | CIB, Calmyrin, KIP, Prkdcip, Sip2-28, Cibkip, Prkdcip, CIBP, DNA-PKcs-interacting protein, Kinase-interacting protein, SNK-interacting protein 2-28 |
Immunogen: | KLH conjugated Synthetic peptide corresponding to Mouse CIB1 |
Isotype: | IgG |
Purity: | Affinity purification |
Predicted MW. | 22 kDa |
Observed MW. | 22 kDa |
Uniprot ID: | Q99828, Q9Z0F4, Q9R010 |
Product Usage Information
Applications | Species | Dilution | Positive tissue |
WB | Human, Mouse, Rat | 1: 500-1: 1000 | heart, testis, kidney |
Background
CIB1(Calcium and integrin binding 1) may convert the inactive conformation of integrin alpha-IIb/beta3 to an active form through binding to the integrin cytoplasmic domain. Induces cell migration and spreading mediated through integrin (possibly via focal adhesion complexes). Functions as a negative regulator of stress activated MAP kinase (MAPK) signaling pathways. May play a role in regulation of apoptosis. Interacts with and up-regulates PTK2 activity. Down regulates inositol 1,4,5-trisphosphate receptor-dependent calcium signaling CIB1 works by inhibiting eurekalert AK1 (p21 protein kinase). When CIB1 activates PAK1, it triggers a series of protein phosphorylation, thereby inhibiting cell migration. CIB1 plays an important role in inhibiting tumor metastasis.
Images
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Western blot analysis of C1B1 (GB11971) at dilution of 1: 500 |
Storage
| Storage | Store at -20°C for one year. Avoid repeated freeze/ thaw cycles. |
| Storage Buffer | PBS with 0.02% sodium azide, 100 μg/ml BSA and 50% glycerol. |
