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Anti-CPSF73 Rabbit pAb (100 μl)
| Reactivity: | M,R & H |
| Applications: | WB & IHC/IF |
| Host Species: | Rabbit |
| Clonality: | Polyclonal |
| Full Name: | CPSF73 rabbit polyclonal antibody |
Gene Name: | Cleavage and polyadenylation specificity factor subunit 3 |
Synonyms: | CPSF, CPSF-73, CPSF 73 kDa subunit, CPSF3, CPSF73, YSH1 |
Immunogen: | Recombinant protein corresponding to Mouse CPSF73 |
Isotype: | IgG |
Purity: | Affinity purification |
Subcellular location: | Nucleus |
Predicted MW. | 78 kDa |
Observed MW. | 70 kDa |
Uniprot ID: | Q9QXK7 |
Product Usage Information
Applications | Species | Dilution | Positive Sample |
WB | Mouse, Rat | 1: 700-1: 1400 | liver |
IHC/IF | Human | 1: 1000-1: 2000 | placenta |
Background
Component of the cleavage and polyadenylation specificity factor (CPSF) complex that plays a key role in pre-mRNA 3'-end formation, recognizing the AAUAAA signal sequence and interacting with poly(A) polymerase and other factors to bring about cleavage and poly(A) addition. Has endonuclease activity, and functions as mRNA 3'-end-processing endonuclease. Also involved in the histone 3'-end pre-mRNA processing. U7 snRNP-dependent protein that induces both the 3' endoribonucleolytic cleavage of histone pre-mRNAs and acts as a 5' to 3' exonuclease for degrading the subsequent downstream cleavage product (DCP) of mature histone mRNAs.
Images
| Western blot analysis of CPSF3 (GB114104) at dilution of 1: 1000 |
| Immunohistochemistry analysis of paraffin embedded human placenta using CPSF3 (GB114104) at dilution of 1: 700 |
Storage
| Storage | Store at -20°C for one year. Avoid repeated freeze/thaw cycles. |
| Storage Buffer | PBS with 0.02%sodium azide,100 μg/ml BSA and 50% glycerol. |
