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| Reactivity: | M |
| Applications: | WB |
| Host Species: | Rabbit |
| Clonality: | Polyclonal |
| Gene Name: | Protein crumbs homolog 3 |
Synonyms: | CRB3, crumbs homolog 3 (Drosophila), Crumbs protein homolog 3 |
Immunogen: | KLH conjugated Synthetic peptide corresponding to Human CRB3 |
Uniprot ID: | Q9BUF7 |
Isotype: | IgG |
Purity: | Affinity purification |
Predicted MW. / Observed MW. | 13 kDa / 13 kDa |
Product Usage Information
WB | Mouse | 1: 800-1: 1500 | lung, kidney |
Background
Involved in the establishment of cell polarity in mammalian epithelial cells. Regulates the morphogenesis of tight junctions. Involved in promoting phosphorylation and cytoplasmic retention of transcriptional coactivators YAP1 and WWTR1/TAZ which leads to suppression of TGFB1-dependent transcription of target genes such as CCN2/CTGF, SERPINE1/PAI1, SNAI1/SNAIL1 and SMAD7.
Images
| Western blot analysis of CRB3 (GB115334) at dilution of 1: 800 |
Storage
| Storage | Store at -20°C for one year. Avoid repeated freeze/thaw cycles. |
| Storage Buffer | PBS with 0.02%sodium azide,100 μg/ml BSA and 50% glycerol. |
