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Anti-CREBBP Rabbit pAb (100 μl)
| Reactivity: | H,M,R |
| Applications: | WB |
| Host Species: | Rabbit |
| Clonality: | Polyclonal |
| Gene Name: | Histone lysine acetyltransferase CREBBP |
Synonyms: | CBP, CREB binding protein, CREBBP, KAT3A, RSTS |
Immunogen: | KLH conjugated Synthetic peptide corresponding to Mouse CREBBP |
Uniprot ID: | P45481 |
Isotype: | lgG |
Purity: | Affinity purification |
Predicted MW. / Observed MW. | 265 kDa / 300 kDa |
Product Usage Information
WB | Human, Mouse, Rat | 1: 300-1: 400 | brain, skin |
Background
Acetylates histones, giving a specific tag for transcriptional activation (By similarity). Also acetylates non-histone proteins, like DDX21, FBL, IRF2, MAFG, NCOA3, POLR1E/PAF53 and FOXO1 Binds specifically to phosphorylated CREB and enhances its transcriptional activity toward cAMP-responsive genes (By similarity). Acts as a coactivator of ALX1 (By similarity). Acts as a circadian transcriptional coactivator which enhances the activity of the circadian transcriptional activators: NPAS2-ARNTL/BMAL1 and CLOCK-ARNTL/BMAL1 heterodimers (By similarity). Acetylates PCNA; acetylation promotes removal of chromatin-bound PCNA and its degradation during nucleotide excision repair (NER)
Images
| WB analysis of CREBBP (GB115518). |
Storage
| Storage | Store at -20°C for one year. Avoid repeated freeze/thaw cycles. |
| Storage Buffer | PBS with 0.02%sodium azide,100 μg/ml BSA and 50% glycerol. |
