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Anti-CRMP3 Rabbit pAb (100 μl)
| Reactivity: | H,M,R |
| Applications: | IHC/IF |
| Host Species: | Rabbit |
| Clonality: | Polyclonal |
| Full Name: | CRMP3 rabbit polyclonal antibody |
Gene Name: | Dihydropyrimidinase-related protein 4 |
Synonyms: | DRP-4, Collapsin response mediator protein 3, CRMP-3, UNC33-like phosphoprotein 4, ULIP-4, Dpysl4, Crmp3, Ulip4 |
Immunogen: | Recombinant protein corresponding to Mouse CRMP3 |
Isotype: | IgG |
Purity: | Affinity purification |
Subcellular location: | Cytoplasm |
Uniprot ID: | O35098, Q62951 |
Product Usage Information
Applications | Species | Dilution | Positive Sample |
IHC/IF | Human, Mouse, Rat | 1: 600-1: 3000 | brain, cervical cancer, epencephalon, laryngocarcinoma, ovary |
Background
CRMP-3 is expressed transiently in developing spinal cord and selectively in the postnatal cerebellum. It is cleaved by Calpain to produce a p54 N-terminal fragment. This cleavage product translocates to the nucleus and induces neuronal death in response to excitotoxicity and cerebral ischemia. Necessary for signaling by class 3 semaphorins and subsequent remodeling of the cytoskeleton. Plays a role in axon guidance, neuronal growth cone collapse and cell migration.
Images
| Immunohistochemistry of paraffin embedded mouse brain using CRMP3 (GB112592) at dilution of 1:650 (400x lens) |
| Immunohistochemistry of paraffin embedded mouse epencephalon using CRMP3 (GB112592) at dilution of 1:650 (400x lens) |
| Immunohistochemistry of paraffin embedded rat brain using CRMP3 (GB112592) at dilution of 1:650 (400x lens) |
| Immunohistochemistry of paraffin embedded rat epencephalon using CRMP3 (GB112592) at dilution of 1:650 (400x lens) |
| Immunofluorescence of paraffin embedded human cervical cancer using CRMP3 (GB112592) at dilution of 1:650 (400x lens) |
| Immunofluorescence of paraffin embedded human laryngocarcinoma using CRMP3 (GB112592) at dilution of 1:650 (400x lens) |
| Immunofluorescence of paraffin embedded mouse brain using CRMP3 (GB112592) at dilution of 1:650 (400x lens) |
| Immunofluorescence of paraffin embedded mouse ovary using CRMP3 (GB112592) at dilution of 1:650 (400x lens) |
Storage
| Storage | Store at -20°C for one year. Avoid repeated freeze/thaw cycles. |
| Storage Buffer | PBS with 0.02%sodium azide,100 μg/ml BSA and 50% glycerol. |
