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Anti-CTDSP2 Rabbit pAb (100 μl)
| Reactivity: | H |
| Applications: | WB |
| Host Species: | Rabbit |
| Clonality: | Polyclonal |
| Full Name: | CTDSP2 rabbit polyclonal antibody |
Gene Name: | Carboxy-terminal domain RNA polymerase II polypeptide A small phosphatase 2 |
Synonyms: | Nuclear LIM interactor-interacting factor 2, NLI-interacting factor 2, rotein OS-4, Small C-terminal domain phosphatase 2, Small CTD phosphatase 2, SCP2, CTDSP2, NIF2, OS4 |
Immunogen: | KLH conjugated Synthetic peptide corresponding to Human CTDSP2 |
Isotype: | IgG |
Purity: | Affinity purification |
Predicted MW. | 31 kDa |
Observed MW. | 35 kDa |
Uniprot ID: | O14595 |
Product Usage Information
Applications | Species | Dilution | Positive Sample |
WB | Human | 1: 500-1: 1000 | 293T, HepG2, K562 |
Background
CTDSPs are C-class phosphatases that act on Ser 5 of the Pol II C-terminal domain (CTD) to decrease transcription. CTDSP enzymatic activity is required for REST function, and knockdown of CTDSP induces the neuronal differentiation of mouse embryonic carcinoma P19 cells. CTDSP2 has been shown to enhance TGF-β signaling by the dephosphorylation of SMAD proteins and attenuates androgen receptor-mediated transcription. It negatively regulates RNA polymerase II transcription by controlling the transition from initiation/capping to processive transcript elongation. It was recruited by REST to neuronal genes that contain RE-1 elements, leading to neuronal gene silencing in non-neuronal cells.
Images
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Western blot analysis of CTDSP2 (GB111407) at dilution of 1: 500 |
Storage
| Storage | Store at -20°C for one year. Avoid repeated freeze/thaw cycles. |
| Storage Buffer | PBS with 0.02%sodium azide,100 μg/ml BSA and 50% glycerol. |
