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Anti-Calcitonin receptor / CT-R Rabbit pAb (100 μl)
| Reactivity: | R |
| Applications: | IHC/IF |
| Host Species: | Rabbit |
| Clonality: | Polyclonal |
| Full Name: | Calcitonin receptor rabbit polyclonal antibody |
Gene Name: | Calcitonin receptor |
Synonyms: | CALCR, CRT, CT-R, CTR, CTR1, calcitonin receptor |
Immunogen: | KLH conjugated Synthetic peptide corresponding to Mouse Calcitonin receptor |
Isotype: | IgG |
Purity: | Affinity purification |
Subcellular location: | Cell membrane |
Uniprot ID: | P32214 |
Product Usage Information
Applications | Species | Dilution | Positive tissue |
IHC/IF | Rat | 1: 500-1: 4000 | bone |
Background
The calcitonin receptor (CT) is a G protein-coupled receptor that binds the peptide hormone calcitonin and is involved in maintenance of calcium homeostasis, particularly with respect to bone formation and metabolism. CT works by activating the G-proteins Gs and Gq often found on osteoclasts, on cells in the kidney, and on cells in a number of regions of the brain. It may also affect the ovaries in women and the testes in men.
The function of the CT receptor protein is modified through its interaction with Receptor activity-modifying proteins (RAMPs), forming the multimeric amylin receptors AMY1 (CT + RAMP1), AMY2 (CT + RAMP2), and AMY3 (CT+ RAMP3).
Images
 |
Immunohistochemistry of paraffin embedded rat bone using calcitionin receptor (GB11587) at dilution of 1:2000 (400x lens) |
Storage
| Storage |
Store at -20°C for one year. Avoid repeated freeze/thaw cycles |
| Storage Buffer |
PBS with 0.02%sodium azide, 100 μg/ml BSA and 50% glycerol. |
