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Anti-Cathepsin K Rabbit pAb (100 μl)
| Reactivity: | M,R |
| Applications: | IHC/IF |
| Host Species: | Rabbit |
| Clonality: | Polyclonal |
| Full Name: | Cathepsin K rabbit polyclonal antibody |
Gene Name: | Cathepsin K |
Synonyms: | Ctsk, Procathepsin K, Cathepsin K, Cathepsin O, Cathepsin X, CTSO |
Immunogen: | Recombinant protein corresponding to Mouse Cathepsin K |
Isotype: | IgG |
Purity: | Affinity purification |
Subcellular location: | Cytoplasm |
Uniprot ID: | P55097, O35186 |
Product Usage Information
Applications | Species | Dilution | Positive Sample |
IHC/IF | Mouse, Rat | 1: 1000-1: 2000 | bone |
Background
The protein encoded by this gene is a lysosomal cysteine proteinase involved in bone remodeling and resorption. This protein, which is a member of the peptidase C1 protein family, is predominantly expressed in osteoclasts. However, the encoded protein is also expressed in a significant fraction of human breast cancers, where it could contribute to tumor invasiveness. Mutations in this gene are the cause of pycnodysostosis an autosomal recessive disease characterized by osteosclerosis and short stature.
Images
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Immunohistochemistry of paraffin embedded mouse bone using Gathepsin-K (GB111276) at dilution of 1:2200 (400x lens) |
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Immunohistochemistry of paraffin embedded rat bone using Gathepsin-K (GB111276) at dilution of 1:2200 (400x lens) |
Storage
| Storage | Store at -20°C for one year. Avoid repeated freeze/ thaw cycles. |
| Storage Buffer | PBS with 0.02% sodium azide, 100 μg/ml BSA and 50% glycerol. |
