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Anti-Claudin 2 Rabbit pAb (100 μl)
| Reactivity: | M,R |
| Applications: | WB |
| Host Species: | Rabbit |
| Clonality: | Polyclonal |
| Full Name: | Claudin-2 rabbit polyclonal antibody |
Gene Name: | Claudin-2 |
Synonyms: | Cldn2, Claudin-2, SP82, CLD2, |
Immunogen: | KLH conjugated Synthetic peptide corresponding to Mouse Claudin-2 |
Isotype: | IgG |
Purity: | Affinity purification |
Predicted MW. | 25 kDa |
Observed MW. | 25 kDa |
Uniprot ID: | P57739, O88552, D4A386 |
Product Usage Information
Applications | Species | Dilution | Positive tissue |
WB | Mouse, Rat | 1: 500-1: 1000 | colon, kidney, small intestine, |
Background
The claudin super family consists of structurally related proteins that are important structural and functional components of tight junctions. Claudin-2, also known as CLDN2 or SP82, is a 230 amino acid multi-pass membrane protein that localizes to the cell junctions and belongs to the claudin super family. Able to form homopolymers of heteropolymers with other claudin family members, claudin-2 plays an essential role in mediating calcium-independent cell-adhesion activity that is necessary for tight junction-specific obliteration of the intercellular space. Overexpression of claudin-2 is associated with a variety of diseases, including lung cancer, colorectal cancer, gastrointestinal carcinomas and inflammatory bowel disease, further affirming the importance of claudin-2 in cell adhesion. The gene encoding claudin-2 maps to human chromosome X, which contains nearly 153 million base pairs and houses over 1,000 genes.
Images
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Western blot analysis of CLD2 (GB11972) at dilution of 1: 500 |
Storage
| Storage | Store at -20°C for one year. Avoid repeated freeze/ thaw cycles. |
| Storage Buffer | PBS with 0.02% sodium azide, 100 μg/ml BSA and 50% glycerol. |
