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Anti-Cortactin Rabbit pAb (100 μl)
| Reactivity: | H,M,R |
| Applications: | WB |
| Host Species: | Rabbit |
| Clonality: | Polyclonal |
| Full Name: | Cortactin rabbit polyclonal antibody |
Gene Name: | Src substrate cortactin |
Synonyms: | Cttn, CTTN, EMS1, Cortactin, Amplaxin, Mammary tumor and squamous cell carcinoma associated, p80/85 src substrate, Src substrate cortactin, SRC8 |
Immunogen: | Recombinant protein corresponding to Mouse Cortactin |
Isotype: | IgG |
Purity: | Affinity purification |
Subcellular location: | 61 kDa |
80 kDa | |
Uniprot ID: |
Product Usage Information
Applications | Species | Dilution | Positive tissue |
WB | Human, Mouse, Rat | 1: 500-1: 1000 | liver, brain |
Background
This gene is overexpressed in breast cancer and squamous cell carcinomas of the head and neck. The encoded protein is localized in the cytoplasm and in areas of the cell-substratum contacts. This gene has two roles: (1) regulating the interactions between components of adherens-type junctions and (2) organizing the cytoskeleton and cell adhesion structures of epithelia and carcinoma cells. During apoptosis, the encoded protein is degraded in a caspase-dependent manner. The aberrant regulation of this gene contributes to tumor cell invasion and metastasis. Three splice variants that encode different isoforms have been identified for this gene.
Images
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Western blot analysis of Cortactin (GB11671) at dilution of 1: 500 |
Storage
| Storage | Store at -20°C for one year. Avoid repeated freeze/ thaw cycles. |
| Storage Buffer | PBS with 0.02% sodium azide, 100 μg/ml BSA and 50% glycerol. |
