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| Reactivity: | H,M,R |
| Applications: | WB |
| Host Species: | Rabbit |
| Clonality: | Polyclonal |
| Full Name: | CrkL rabbit polyclonal antibody |
Gene Name: | Crk-like protein |
Synonyms: | Crkl, CRKL, CRK like proto-oncogene, Adaptor protein |
Immunogen: | Recombinant protein corresponding to Mouse CrkL |
Isotype: | IgG |
Purity: | Affinity purification |
Predicted MW. | 34 kDa |
Observed MW. | 39 kDa |
Uniprot ID: | P46109, P47941, Q5U2U2 |
Product Usage Information
Applications | Species | Dilution | Positive tissue |
WB | Human, Mouse, Rat | 1: 500-1: 1000 | brain |
Background
V-CRK avian sarcoma virus CT10-homolog-like contains one SH2 domain and two SH3 domains. Crk-like protein encoded by the CRKL gene, has been shown to activate the RAS and JUN kinase signaling pathways and transform fibroblasts in a RAS-dependent fashion. It is a substrate of the BCR-ABL tyrosine kinase and plays a role in fibroblast transformation by BCR-ABL. In addition, CRKL has oncogenic potential. CrkL together with Crk participates in the Reelin signaling cascade downstream of DAB1.
Images
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Western blot analysis of crkl (GB11756) at dilution of 1: 500 |
Storage
| Storage | Store at -20°C for one year. Avoid repeated freeze/ thaw cycles. |
| Storage Buffer | PBS with 0.02% sodium azide, 100 μg/ml BSA and 50% glycerol. |
