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Anti-Cyclin A2 Rabbit pAb (100 μl)
| Reactivity: | H,M & H,M,R & H,M |
| Applications: | WB & IHC/IF & ICC/IF |
| Host Species: | Rabbit |
| Clonality: | Polyclonal |
| Gene Name: | Cyclin-A2 |
Synonyms: | Cyclin-A, Ccna2, CycA, CycA2, Cyclin A2, Cyclin A, CCNA2, CCNA, CCN1 |
Immunogen: | Recombinant protein corresponding to Human Cyclin A2 |
Uniprot ID: | P20248 |
Isotype: | IgG |
Purity: | Affinity purification |
Subcellular location: | Nucleus, Cytoplasm |
Predicted MW. / Observed MW. | 49 kDa / 55 kDa |
Images
WB | Human, Mouse | 1: 500-1: 1000 | spleen, lymph node |
IHC/IF | Human, Mouse, Rat | 1: 250-1: 1200 | lymph, brain, lung cancer |
ICC/IF | Human, Mouse | 1: 50-1: 200 | HeLa |
Background
Cyclin A2 belongs to the highly conserved cyclin family, whose members are characterized by a dramatic periodicity in protein abundance through the cell cycle. Cyclins function as regulators of CDK kinases. Different cyclins exhibit distinct expression and degradation patterns which contribute to the temporal coordination of each mitotic event. In contrast to cyclin A1, which is present only in germ cells, this cyclin is expressed in all tissues tested. Cyclin A2 binds and activates CDC2 or CDK2 kinases, and thus promotes both cell cycle G1/S and G2/M transitions. Cyclin A2 could be phosphorylated during the G2/M.
Images
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Western blot analysis of cyclin a (GB111132) at dilution of 1: 1000 |
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Immunohistochemistry analysis of paraffin embedded rat testis using cyclin a (GB111132) at dilution of 1: 600 |
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Immunohistochemistry analysis of paraffin embedded rat lymph using cyclin a (GB111132) at dilution of 1: 600 |
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Immunohistochemistry analysis of paraffin embedded mouse lymph using cyclin a (GB111132) at dilution of 1: 600 |
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Immunohistochemistry analysis of paraffin embedded mouse brain using cyclin a (GB111132) at dilution of 1: 600 |
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Immunohistochemistry analysis of paraffin embedded human lymph gland using cyclin a (GB111132) at dilution of 1: 1200 |
| Immunofluorescent analysis of paraffin embedded mouse placenta using cyclin a (GB111132) at dilution of 1: 500 |
| Immunofluorescent analysis of paraffin embedded human lung cancer using cyclin a (GB111132) at dilution of 1: 500 |
| Immunocytochemistry analysis of 4% paraformaldehyde-fixed HeLa cells using Cyclin A2(GB111132) at dilution of 1:50-1:200 |
| Immunocytochemistry analysis of 4% paraformaldehyde-fixed HeLa cells using Cyclin A2(GB111132) at dilution of 1:50-1:200 |
Storage
| Storage | Store at -20°C for one year. Avoid repeated freeze/ thaw cycles. |
| Storage Buffer | PBS with 0.02% sodium azide, 100 μg/ml BSA and 50% glycerol. |
