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| Reactivity: | H,M,R |
| Applications: | IHC/IF |
| Host Species: | Rabbit |
| Clonality: | Polyclonal |
| Full Name: | DTX1 rabbit polyclonal antibody |
Gene Name: | E3 ubiquitin-protein ligase DTX1 |
Synonyms: | FXI-T1, Protein deltex-1, Deltex1, mDTX1, RING-type E3 ubiquitin transferase DTX1, Dtx1 |
Immunogen: | Recombinant protein corresponding to Mouse DTX1 |
Isotype: | IgG |
Purity: | Affinity purification |
Subcellular location: | Cytoplasm, Nucleus |
Uniprot ID: | Q61010 |
Applications
Applications | Species | Dilution | Positive Sample |
IHC/IF | Human, Mouse, Rat | 1: 200-1: 1200 | brain, colon, kidney, lung, lymph node, spinal cord |
Background
The Deltex homolog 1 (E3 ubiquitin-protein ligase DTX1) functions as a ubiquitin ligase protein in vivo, mediating ubiquitination and promoting degradation of MEKK1, suggesting that it may regulate the Notch pathway via some ubiquitin ligase activity (By similarity). Regulator of Notch signaling, a signaling pathway involved in cell-cell communications that regulates a broad spectrum of cell-fate determinations. Mainly acts as a positive regulator of Notch, but it also acts as a negative regulator, depending on the developmental and cell context.
Images
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Immunohistochemistry of paraffin embedded human colon using deltex (GB111202) at dilution of 1:600 (400x lens) |
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Immunohistochemistry of paraffin embedded mouse lung using deltex (GB111202) at dilution of 1:600 (400x lens) |
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Immunohistochemistry of paraffin embedded mouse lymph node using deltex (GB111202) at dilution of 1:600 (400x lens) |
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Immunohistochemistry of paraffin embedded rat brain using deltex (GB111202) at dilution of 1:600 (400x lens) |
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Immunohistochemistry of paraffin embedded rat kidney using deltex (GB111202) at dilution of 1:600 (400x lens) |
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Immunohistochemistry of paraffin embedded rat lymph node using deltex (GB111202) at dilution of 1:600 (400x lens) |
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Immunofluorescence of paraffin embedded mouse spinal cord using deltex (GB111202) at dilution of 1:200 (400x lens) |
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Immunofluorescence of paraffin embedded rat brain using deltex (GB111202) at dilution of 1:200 (400x lens) |
Storage
| Storage | Store at -20°C for one year. Avoid repeated freeze/ thaw cycles. |
| Storage Buffer | PBS with 0.02% sodium azide, 100 μg/ml BSA and 50% glycerol. |
