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Anti-Doublecortin Rabbit pAb (100 μl)
| Reactivity: | M,R |
| Applications: | IHC/IF |
| Host Species: | Rabbit |
| Clonality: | Polyclonal |
| Gene Name: | Neuronal migration protein doublecortin |
Synonyms: | DBCN, Dbct, DC, DCX, Doublecortex, Doublin, Lis-X, Lissencephalin X, SCLH, XLIS |
Immunogen: | KLH conjugated Synthetic peptide corresponding to the C-terminus of Mouse Doublecortin. |
Uniprot ID: | O88809 |
Isotype: | IgG |
Purity: | Affinity purification |
Subcellular location: | Cytoplasm |
Product Usage Information
IHC/IF | Mouse, Rat | 1: 200-1: 1000 | brain, hippocampus |
Background
Seems to be required for initial steps of neuronal dispersion and cortex lamination during cerebral cortex development. May act by competing with the putative neuronal protein kinase DCAMKL1 in binding to a target protein. May in that way participate in a signaling pathway that is crucial for neuronal interaction before and during migration, possibly as part of a calcium ion-dependent signal transduction pathway. May be part with LIS-1 of an overlapping, but distinct, signaling pathways that promote neuronal migration.
Images
| Immunohistochemistry analysis of paraffin embedded mouse brain using DCX (GB114319) at dilution of 1: 1000 |
| Immunohistochemistry analysis of paraffin embedded mouse hippocampus using DCX (GB114319) at dilution of 1: 1000 |
| Immunohistochemistry analysis of paraffin embedded Rat brain using DCX (GB114319) at dilution of 1: 500 |
Storage
| Storage | Store at -20°C for one year. Avoid repeated freeze/thaw cycles. |
| Storage Buffer | PBS with 0.02%sodium azide,100 μg/ml BSA and 50% glycerol. |
