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Anti-ERCC1 Rabbit pAb (100 μl)
| Reactivity: | H & H,M |
| Applications: | WB & IHC |
| Host Species: | Rabbit |
| Clonality: | Polyclonal |
| Full Name: | ERCC1 rabbit polyclonal |
Gene Name: | DNA excision repair protein ERCC-1 |
Synonyms: | Ercc-1, UV20, COFS4, excision repair cross-complementation group 1, excision repair cross-complementing 1, ERCC1 |
Immunogen: | Recombinant protein corresponding to Mouse ERCC1 |
Isotype: | IgG |
Purity: | Affinity purification |
Subcellular location: | |
Predicted MW. | 33 kDa |
Observed MW. | 38 kDa |
Uniprot ID: |
Product Usage Information
Applications | Species | Dilution | Positive tissue |
| WB | Human | 1: 500-1: 1000 | HeLa, MCF7, HepG2 |
IHC | Human, Mouse | 1: 1000-1: 2000 | colon cancer, esophageal cancer, lung cancer,lung,Bliver, spinal cord, spleen |
Background
Excision Repair Cross Complementing 1 (ERCC1) is a structure-specific endonuclease that is responsible for the 5-incision during damaged-DNA repair. It forms a complex with ERCC11, XPF and ERCC4, which are required in both recombinatorial repair and nucleotide excision repair. It has been found that ERCC1, together with RRM1, are determinants of survival after surgical treatment of early-stage, non-small-cell lung cancer.
Images
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Western blot analysis of ERCC1 (GB111374) at dilution of 1: 1000 Lane 1: Hela cell lysate Lane 2: MCF7 cell lysate Lane 3: HepG2 cell lysate |
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Immunohistochemistry analysis of paraffin-embedded human colon cancer using Ercc1 (GB111374) at dilution of 1: 1000 |
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Immunohistochemistry analysis of paraffin-embedded human esophageal cancer using Ercc1 (GB111374) at dilution of 1: 1000 |
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Immunohistochemistry analysis of paraffin-embedded human lung cancer using Ercc1 (GB111374) at dilution of 1: 1000 |
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Immunohistochemistry analysis of paraffin-embedded mouse lung using Ercc1 (GB111374) at dilution of 1: 1000 |
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Immunohistochemistry analysis of paraffin-embedded mouse liver using Ercc1 (GB111374) at dilution of 1: 1000 |
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Immunohistochemistry analysis of paraffin-embedded mouse spinal cord using Ercc1 (GB111374) at dilution of 1: 1000 |
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Immunohistochemistry analysis of paraffin-embedded mouse spleen using Ercc1 (GB111374) at dilution of 1: 1000 |
Storage
| Storage | Store at -20°C for one year. Avoid repeated freeze/thaw cycles. |
| Storage Buffer | PBS with 0.02%sodium azide,100 μg/ml BSA and 50% glycerol. |
