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| Reactivity: | H,M,R & H,R,M |
| Applications: | WB & IHC/IF |
| Host Species: | Rabbit |
| Clonality: | Polyclonal |
| Full Name: | EVI1 rabbit polyclonal antibody |
Gene Name: | Histone-lysine N-methyltransferase MECOM |
Synonyms: | Ecotropic virus integration site 1 protein, EVI-1, MDS1 and EVI1 complex locus protein, Myelodysplasia syndrome 1 protein homolog, Mecom, Evi1, Mds1, Prdm3 |
Immunogen: | KLH conjugated Synthetic peptide corresponding to Mouse EVI1 |
Isotype: | IgG |
Purity: | Affinity purification |
Subcellular location: | Cytoplasm, Nucleus |
Predicted MW. | 138 kDa |
Observed MW. | 118 kDa |
Uniprot ID: | P14404 |
Product Usage Information
Applications | Species | Dilution | Positive Sample |
WB | Human, Mouse | 1: 500-1: 1000 | SKOV3 |
IHC/IF | Mouse, Rat | 1: 700-1: 4000 | kidney, liver, stomach |
Background
The protein encoded by this gene is a transcriptional regulator and oncoprotein that may be involved in hematopoiesis, apoptosis, development, and cell differentiation and proliferation. The encoded protein can interact with CTBP1, SMAD3, CREBBP, KAT2B, MAPK8, and MAPK9. This gene can undergo translocation with the AML1 gene, resulting in overexpression of this gene and the onset of leukemia. Several transcript variants encoding a few different isoforms have been found for this gene.
Images
| Western blot analysis of MECOM (GB112580) at dilution of 1: 500 |
| Immunohistochemistry of paraffin embedded mouse kidney using MECOM (GB112580) at dilution of 1: 2200 (400x lens) |
| Immunohistochemistry of paraffin embedded mouse liver using MECOM (GB112580) at dilution of 1: 2200 (400x lens) |
| Immunohistochemistry of paraffin embedded mouse stomach using MECOM (GB112580) at dilution of 1: 2200 (400x lens) |
 | Immunofluorescence of paraffin embedded mouse stomach using MECOM (GB112580) at dilution of 1: 700 (400x lens) |
Storage
| Storage | Store at -20°C for one year. Avoid repeated freeze/thaw cycles. |
| Storage Buffer | PBS with 0.02%sodium azide,100 μg/ml BSA and 50% glycerol. |
