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Anti-EVI2B Rabbit pAb (100 μl)
| Reactivity: | H,M |
| Applications: | WB |
| Host Species: | Rabbit |
| Clonality: | Polyclonal |
| Full Name: | EVI2B rabbit polyclonal antibody |
Gene Name: | Protein EVI2B |
Synonyms: | Ecotropic viral integration site 2B protein, EVI-2B, CD361, Evi2b, EVDB, EVI2B protein, Protein EVI2B |
Immunogen: | Recombinant protein corresponding to Mouse EVI2B |
Isotype: | IgG |
Purity: | Affinity purification |
Predicted MW. | 48 kDa |
Observed MW. | 65 kDa |
Uniprot ID: | P34910, Q8VD58 |
Product Usage Information
Applications | Species | Dilution | Positive tissue |
WB | Human, Mouse | 1: 500-1: 1000 | lymph node |
Background
EVI2B is a 448 amino acid protein which functions in the differentiation of melanocytes and keratinocytes. Lying within an intron of the Neurofibromin gene, the gene encoding EVI2B is transcribed from the telomere toward the centromere, which is opposite the transcription direction of the Neurofibromin gene. EVI2B is a single-pass transmembrane protein containing an extracellular domain with 4 glycosylation sites, a N-terminal signal peptide, a cytoplasmic hydrophilic domain and a hydrophobic transmembrane domain. Due to evidence suggesting that gene encoding the mouse homolog lies within a viral integration site that has been identitified in retrovirus-induced myeloid tumors, the gene encoding EVI2B may function as an oncogene in these tumor types.
Images
 | Western blot analysis of CD361 (GB112973) at dilution of 1: 500 |
Storage
| Storage | Store at -20°C for one year. Avoid repeated freeze/thaw cycles. |
| Storage Buffer | PBS with 0.02%sodium azide,100 μg/ml BSA and 50% glycerol. |
