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Anti-ErbB2 Rabbit pAb (100 μl)
| Reactivity: | H & H |
| Applications: | WB & IHC/IF |
| Host Species: | Rabbit |
| Clonality: | Polyclonal |
| Gene Name: | Erb-b2 receptor tyrosine kinase 2 |
Synonyms: | CD340, ERBB2, HER 2, HER 2/neu, HER2, MLN 19, MLN19, NEU, NGL, p185, p185erbB2, Proto oncogene c ErbB 2, Proto oncogene Neu, TKR1 |
Immunogen: | Recombinant protein corresponding to Human ErbB2 / HER2 |
Uniprot ID: | P04626 |
Isotype: | IgG |
Purity: | Affinity purification |
Subcellular location: | Endosome, Cell membrane, Nucleus |
Predicted MW. / Observed MW. | 138 kDa / 185 kDa |
Product Usage Information
Applications | Species | Dilution | Positive Sample |
WB | Human | 1: 1000-1: 2000 | SK-BR-3, SK-OV-3 |
IHC/IF | Human | 1: 500-1: 1000 | breast cancer |
Background
HER2, also known as ErbB2 and Neu, is a 185-kDa transmembrane glycoprotein that is a member of the epidermal growth factor (EGF) receptor family of receptor tyrosine kinases. It has no ligand binding domain of its own and therefore cannot bind growth factors. However, it does bind tightly to other ligand-bound EGF receptor family members to form a heterodimer, stabilizing ligand binding and enhancing kinase-mediated activation of downstream signalling pathways, such as those involving mitogen-activated protein kinase and phosphatidylinositol-3 kinase.
Images
 | Western blot analysis of ERBB2 (GB113971) at dilution of 1: 1000 |
 | Immunohistochemistry of paraffin embedded human breast cancer using ERBB2 (GB113971) at dilution of 1: 1000 (400x lens) |
Storage
| Storage | Store at -20°C for one year. Avoid repeated freeze/thaw cycles. |
| Storage Buffer | PBS with 0.02%sodium azide,100 μg/ml BSA and 50% glycerol. |
