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Anti-Fascin Mouse mAb (100 μl)
| Reactivity: | H & H |
| Applications: | WB & IHC/IF |
| Host Species: | Mouse |
| Clonality: | Monoclonal |
| Gene Name: | Fascin |
Synonyms: | Singed-like protein, Fscn1, Fan1, Snl, HSN, p55, SNL |
Immunogen: | KLH conjugated Synthetic peptide corresponding to Human Fascin |
Uniprot ID: | Q16658 |
Isotype: | IgG1,κ |
Purity: | Affinity purification |
Subcellular location: | Cytoplasm |
Predicted MW. / Observed MW. | 55 kDa / 55 kDa |
Product Usage Information
WB | Human | 1: 300-1: 500 | HeLa, Hep G2 |
IHC/IF | Human | 1: 500-1: 1000 | colorectal carcinoma, cervical carcinoma, bladder cancer |
Background
Fascin is a highly conserved and ubiquitous actin cross-linking protein that has a major function in cell motility and adhesion. Fascin localizes to a number of highly dynamic cellular structures that require strong mechanical support which include stress fibers and cellular protrusions such as microvilli, microspikes and lamellipodia. Fascin is up-regulated in many human carcinomas. It’s a marker for Reed-Sternberg cells in Hodgkin's disease; it is also a highly selective marker for dendritic cells of lymphoid tissues.
Images
| Western blot analysis of Fascin (GB121026) at dilution of 1: 1000 |
| Immunohistochemistry analysis of paraffin embedded human colorectal carcinoma using fascin (GB121026) at dilution of 1: 500 |
| Immunohistochemistry analysis of paraffin embedded human cervical carcinoma using fascin (GB121026) at dilution of 1: 500 |
| Immunohistochemistry analysis of paraffin embedded human bladder cancer using fascin (GB121026) at dilution of 1: 500 |
Storage
| Storage | Store at -20°C for one year. Avoid repeated freeze/thaw cycles. |
| Storage Buffer | PBS with 0.02%sodium azide,100 μg/ml BSA and 50% glycerol. |
