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Anti-Fragilis Rabbit pAb (100 μl)
| Reactivity: | H,M,R & R |
| Applications: | WB & IHC/IF |
| Host Species: | Rabbit |
| Clonality: | Polyclonal |
| Full Name: | Fragilis rabbit polyclonal antibody |
Gene Name: | Interferon-induced transmembrane protein 3 |
Synonyms: | 1 8U, Fragilis, IFITM3, IP15 |
Immunogen: | KLH conjugated Synthetic peptide corresponding to Mouse Fragilis |
Isotype: | IgG |
Purity: | Affinity purification |
Subcellular location: | Cell membrane |
Predicted MW. | 15 kDa |
Observed MW. | 14 kDa |
Uniprot ID: | Q9CQW9 |
Product Usage Information
Applications | Species | Dilution | Positive Sample |
WB | Human, Mouse, Rat | 1: 1600-1: 3200 | colon |
IHC/IF | Rat | 1: 1000-1: 2000 | liver, placenta |
Background
IFN-induced antiviral protein which disrupts intracellular cholesterol homeostasis. Inhibits the entry of viruses to the host cell cytoplasm by preventing viral fusion with cholesterol depleted endosomes. May inactivate new enveloped viruses which buds out of the infected cell, by letting them go out with a cholesterol depleted membrane. Active against multiple viruses, including influenza A virus, SARS coronaviruses (SARS-CoV and SARS-CoV-2), Marburg virus (MARV), Ebola virus (EBOV), Dengue virus (DNV), West Nile virus (WNV), human immunodeficiency virus type 1 (HIV-1), hepatitis C virus (HCV) and vesicular stomatitis virus (VSV).
Images
| Western blot analysis of IFITM3 (GB114087) at dilution of 1: 2000 |
| Immunohistochemistry analysis of paraffin embedded rat liver using IFITM3 (GB114087) at dilution of 1: 1600 |
| Immunohistochemistry analysis of paraffin embedded rat placenta using IFITM3 (GB114087) at dilution of 1: 1600 |
| Immunofluorescence of paraffin embedded rat liver using IFITM3 (GB114087) at dilution of 1: 1600 |
| Immunofluorescence of paraffin embedded rat placenta using IFITM3 (GB114087) at dilution of 1: 1600 |
Storage
| Storage | Store at -20°C for one year. Avoid repeated freeze/thaw cycles. |
| Storage Buffer | PBS with 0.02%sodium azide,100 μg/ml BSA and 50% glycerol. |
