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| Reactivity: | H |
| Applications: | WB |
| Host Species: | Rabbit |
| Clonality: | Polyclonal |
| Gene Name: | Ras GTPase-activating protein-binding protein 1 |
Synonyms: | G3BP, G3BP 1, G3BP1, HDH VIII |
Immunogen: | KLH conjugated Synthetic peptide corresponding to Mouse G3BP |
Uniprot ID: | P97855 |
Isotype: | lgG |
Purity: | Affinity purification |
Predicted MW. / Observed MW. | 52 kDa / 68 kDa |
Product Usage Information
WB | Human | 1: 300-1: 600 | Hela, Jurkat |
Background
ATP- and magnesium-dependent helicase that plays an essential role in innate immunity. Participates in the DNA-triggered cGAS/STING pathway by promoting the DNA binding and activation of CGAS. Enhances also DDX58-induced type I interferon production probably by helping DDX58 at sensing pathogenic RNA. In addition, plays an essential role in stress granule formation. Unwinds preferentially partial DNA and RNA duplexes having a 17 bp annealed portion and either a hanging 3' tail or hanging tails at both 5'- and 3'-ends. Unwinds DNA/DNA, RNA/DNA, and RNA/RNA substrates with comparable efficiency. Acts unidirectionally by moving in the 5' to 3' direction along the bound single-stranded DNA. Phosphorylation-dependent sequence-specific endoribonuclease in vitro Cleaves exclusively between cytosine and adenine and cleaves MYC mRNA preferentially at the 3'-UTR
Images
| WB analysis of G3BP1 (GB115527). |
Storage
| Storage | Store at -20°C for one year. Avoid repeated freeze/thaw cycles. |
| Storage Buffer | PBS with 0.02%sodium azide,100 μg/ml BSA and 50% glycerol. |
