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Anti-GABA A Receptor alpha 1 Rabbit pAb (100 μl)
| Reactivity: | H,M,R |
| Applications: | IHC/IF |
| Host Species: | Rabbit |
| Clonality: | Polyclonal |
| Full Name: | GABA A Receptor alpha 1 rabbit polyclonal antibody |
Gene Name: | Gamma-aminobutyric acid receptor subunit alpha-1 |
Synonyms: | Gabra1, GABRA1, ECA4, EIEE19, EJM, EJM5, gamma-aminobutyric acid type A receptor alpha1 subunit, GABA A Receptor alpha 1 |
Immunogen: | KLH conjugated Synthetic peptide corresponding to Mouse GABA A Receptor alpha 1 |
Isotype: | IgG |
Purity: | Affinity purification |
Subcellular location: | Membrane, Secreted |
Uniprot ID: | P62812 |
Product Usage Information
Applications | Species | Dilution | Positive Sample |
IHC/IF | Human, Mouse, Rat | 1: 300-1: 1500 | brain, cerebellum, glioblastoma multiforme |
Background
Gamma-aminobutyric acid receptor subunit alpha-1 is a protein that in humans is encoded by the GABRA1 gene. GABA is the major inhibitory neurotransmitter in the mammalian brain where it acts at GABA-A receptors, which are ligand-gated chloride channels. Chloride conductance of these channels can be modulated by agents such as benzodiazepines that bind to the GABA-A receptor. At least 16 distinct subunits of GABA-A receptors have been identified. The GABRA1 receptor is the specific target of the z-drug class of nonbenzodiazepine hypnotic agents and is responsible for their hypnotic and hallucinogenic effects.
Images
| Immunohistochemistry of paraffin embedded human brain using GABRA1 (GB11716) at dilution of 1:600 |
| Immunohistochemistry of paraffin embedded mouse brain using GABRA1 (GB11716) at dilution of 1:600 |
| Immunohistochemistry of paraffin embedded rat brain using GABRA1 (GB11716) at dilution of 1:600 |
| Immunohistochemistry of paraffin embedded rat brain using GABRA1 (GB11716) at dilution of 1:600 |
| Immunohistochemistry of paraffin embedded human glioblastoma multiforme using GABRA1 (GB11716) at dilution of 1:600 |
| Immunohistochemistry of paraffin embedded mouse cerebellum using GABRA1 (GB11716) at dilution of 1:600 |
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Immunohistochemistry of paraffin embedded rat cerebellum using GABRA1 (GB11716) at dilution of 1:600 |
Storage
| Storage | Store at -20°C for one year. Avoid repeated freeze/ thaw cycles. |
| Storage Buffer | PBS with 0.02% sodium azide, 100 μg/ml BSA and 50% glycerol. |
