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Anti-GABA A Receptor beta 2/GABRB2 Rabbit pAb (100 μl)
| Reactivity: | H & M |
| Applications: | WB & IHC/IF |
| Host Species: | Rabbit |
| Clonality: | Polyclonal |
| Gene Name: | Gamma-aminobutyric acid receptor subunit beta-2 |
Synonyms: | GABA, GABRB2, GABA(A) receptor subunit beta-2, GABA(A) receptor beta 2 |
Immunogen: | KLH conjugated Synthetic peptide corresponding to Mouse GABA A Receptor beta 2/GABRB2 |
Uniprot ID: | P63137 |
Isotype: | IgG |
Purity: | Affinity purification |
Subcellular location: | Cell junction, Cell membrane |
Predicted MW. / Observed MW. | 59 kDa / 59 kDa |
Product Usage Information
WB | Human | 1: 1500-1: 3000 | Hep G2, A549 |
IHC/IF | Mouse | 1: 1000-1: 3000 | cerebellum |
Background
Ligand-gated chloride channel which is a component of the heteropentameric receptor for GABA, the major inhibitory neurotransmitter in the brain . Plays an important role in the formation of functional inhibitory GABAergic synapses in addition to mediating synaptic inhibition as a GABA-gated ion channel . The gamma2 subunit is necessary but not sufficient for a rapid formation of active synaptic contacts and the synaptogenic effect of this subunit is influenced by the type of alpha and beta subunits present in the receptor pentamer . The alpha1/beta2/gamma2 receptor and the alpha2/beta2/gamma2 receptor exhibit synaptogenic activity . Functions also as histamine receptor and mediates cellular responses to histamine.
Images
| Western blot analysis of GABRB2 (GB114791) at dilution of 1: 1500 |
| Immunofluorescence of paraffin embedded mouse cerebellum using GABRB2 (GB114791) at dilution of 1: 300 |
| Immunofluorescence of paraffin embedded mouse cerebellum using GABRB2 (GB114791) at dilution of 1: 300 |
Storage
| Storage | Store at -20°C for one year. Avoid repeated freeze/thaw cycles. |
| Storage Buffer | PBS with 0.02%sodium azide,100 μg/ml BSA and 50% glycerol. |
