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| Reactivity: | H |
| Applications: | IHC/IF |
| Host Species: | Rabbit |
| Clonality: | Polyclonal |
| Full Name: | GBP1 rabbit polyclonal antibody |
Gene Name: | Guanylate-binding protein 1 |
Synonyms: | GBP-1, GBP1, GTP binding protein 1, HuGBP1, HuGBP-1 |
Immunogen: | Recombinant protein corresponding to Mouse GBP1 |
Isotype: | IgG |
Purity: | Affinity purification |
Predicted MW. | 68 kDa |
Observed MW. | 68 kDa |
Uniprot ID: | Q01514 |
Product Usage Information
Applications | Species | Dilution | Positive Sample |
WB | Mouse, Rat | 1: 700-1: 1400 | spleen, liver |
Background
Guanylate binding protein 1 (GBP1) belongs to the dynamin superfamily of large GTPases. The expression of GBP1 is induced by interferon and GBP1 is characterized by its ability to specifically bind guanine nucleotides such as GMP, GDP, and GTP and its ability to hydrolyze GTP to GDP and GMP. GBP1 is induced in response to type I and type II interferons and as such plays a role in protective immunity against a spectrum of intracellular pathogens ranging from viruses to bacteria to protozoa, such as negative-strand RNA Rhabdovirus, vesicular stomatitis virus and the positive-strand RNA Picornovirus, encephalomyocarditis virus in cultured cells, the inhibition of Chlamydia trachomatis, Toxoplasma gondii, and Salmonella enterica.
Images
 | Western blot analysis of GBP1 (GB113991) at dilution of 1: 1000 |
 | Western blot analysis of GBP1 (GB113991) at dilution of 1: 1000 |
Storage
| Storage | Store at -20°C for one year. Avoid repeated freeze/thaw cycles. |
| Storage Buffer | PBS with 0.02%sodium azide,100 μg/ml BSA and 50% glycerol. |
