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| Reactivity: | R & R |
| Applications: | IHC & IF |
| Host Species: | Rabbit |
| Clonality: | Polyclonal |
| Full Name: | GIV rabbit polyclonal |
Gene Name: | Girdin |
Synonyms: | Ccdc88a, CCDC88A, APE, GIRDIN, GIV, GRDN, HkRP1, KIAA1212, Coiled-coil domain containing 88A, PEHO, PEHOL, Girdin |
Immunogen: | Recombinant protein corresponding to Mouse Girdin |
Isotype: | IgG |
Purity: | Affinity purification |
Subcellular location: | Cytoplasm, Cell membrane |
Uniprot ID: |
Product Usage Information
Applications | Species | Dilution | Positive tissue |
IHC | Rat | 1: 1000-1: 4000 | testis, brain |
IF | Rat | 1: 500-1: 1000 | testis, brain |
Background
Plays a role as a key modulator of the AKT-mTOR signaling pathway controlling the tempo of the process of newborn neurons integration during adult neurogenesis, including correct neuron positioning, dendritic development and synapse formation. Enhances phosphoinositide 3-kinase (PI3K)-dependent phosphorylation and kinase activity of AKT1/PKB, but does not possess kinase activity itself. Phosphorylation of AKT1/PKB thereby induces the phosphorylation of downstream effectors GSK3 and FOXO1/FKHR, and regulates DNA replication and cell proliferation (By similarity). Essential for the integrity of the actin cytoskeleton and for cell migration. Required for formation of actin stress fibers and lamellipodia. May be involved in membrane sorting in the early endosome.
Images
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Immunohistochemistry analysis of paraffin-embedded rat testis using Girdin (GB11908) at dilution of 1: 1500 |
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Immunohistochemistry analysis of paraffin-embedded rat brain using Girdin (GB11908) at dilution of 1: 1500 |
Storage
| Storage | Store at -20°C for one year. Avoid repeated freeze/ thaw cycles. |
| Storage Buffer | PBS with 0.02% sodium azide, 100 μg/ml BSA and 50% glycerol. |
