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| Reactivity: | H,M |
| Applications: | WB |
| Host Species: | Rabbit |
| Clonality: | Polyclonal |
| Gene Name: | Guanine nucleotide-binding protein G(s) subunit alpha isoforms short |
Synonyms: | Gnas, Gnas1, MNCb-5546 |
Immunogen: | KLH conjugated Synthetic peptide corresponding to Mouse Gα |
Uniprot ID: | P63094 |
Isotype: | lgG |
Purity: | Affinity purification |
Predicted MW. / Observed MW. | 46/44/42 kDa / 46 kDa |
Product Usage Information
WB | Human, Mouse | 1: 300-1: 600 | skeletal muscle |
Background
Guanine nucleotide-binding proteins (G proteins) function as transducers in numerous signaling pathways controlled by G protein-coupled receptors (GPCRs). Signaling involves the activation of adenylyl cyclases, resulting in increased levels of the signaling molecule cAMP. GNAS functions downstream of several GPCRs, including beta-adrenergic receptors. Stimulates the Ras signaling pathway via RAPGEF2.
Images
| WB analysis of Gα (GB115504). Sample: Protein treated by RIPA Lysis Buffer (G2002). Blocking buffer: 3% Nonfat dry milk (GC310001) in TBST, RT, 1h. Primary antibody: 1: 300, 4°C overnight. Secondary antibody: HRP Goat Anti-Rabbit lgG (GB23303), 1: 3000, RT, 1h. |
Storage
| Storage | Store at -20°C for one year. Avoid repeated freeze/thaw cycles. |
| Storage Buffer | PBS with 0.02%sodium azide,100 μg/ml BSA and 50% glycerol. |
