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| Reactivity: | H,M,R |
| Applications: | IF |
| Host Species: | Rabbit |
| Clonality: | Polyclonal |
| Full Name: | GNE rabbit polyclonal |
Gene Name: | Bifunctional UDP-N-acetylglucosamine 2-epimerase/N-acetylmannosamine kinase |
Synonyms: | UDP-GlcNAc-2-epimerase/ManAc kinase, N-acetylmannosamine kinase, ManAc kinase, Gne, Glcne, Uae1, UDP-GlcNAc-2-epimerase |
Immunogen: | KLH conjugated Synthetic peptide corresponding to Mouse GNE |
Isotype: | IgG |
Purity: | Affinity purification |
Subcellular location: | |
Uniprot ID: |
Product Usage Information
Applications | Species | Dilution | Positive tissue |
IF | Human, Mouse, Rat | 1: 300-1: 600 | placenta, lung, kidney |
Background
The bifunctional enzyme UDP-N-acetylglucosamine-2-epimerase/N-acetylmannosamine kinase (GNE) is essential for early embryonic development and catalyzes the rate limiting step in sialic acid biosynthesis. It plays an important role in neuronal cell and brain development, and is strongly involved in cardiac tissue and skeletal muscle early survival and organization.. This protein has 5 isoforms produced by alternative splicing.
Images
| Immunofluorescent analysis of paraformaldehyde-fixed human placenta using GNE (GB112704) at dilution of 1: 600 |
| Immunofluorescent analysis of paraformaldehyde-fixed human lung using GNE (GB112704) at dilution of 1: 600 |
| Immunofluorescent analysis of paraformaldehyde-fixed mouse lung using GNE (GB112704) at dilution of 1: 600 |
| Immunofluorescent analysis of paraformaldehyde-fixed rat lung using GNE (GB112704) at dilution of 1: 600 |
| Immunofluorescent analysis of paraformaldehyde-fixed rat kidney using GNE (GB112704) at dilution of 1: 600 |
Storage
| Storage | Store at -20°C for one year. Avoid repeated freeze/thaw cycles. |
| Storage Buffer | PBS with 0.02%sodium azide,100 μg/ml BSA and 50% glycerol. |
