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Anti-GPR161 Rabbit pAb (100 μl)
| Reactivity: | M,R |
| Applications: | WB |
| Host Species: | Rabbit |
| Clonality: | Polyclonal |
| Full Name: | GPR161 rabbit polyclonal antibody |
Gene Name: | G-protein coupled receptor 161 |
Synonyms: | Gpr161, Gm208, RE2, G protein coupled receptor RE2 |
Immunogen: | KLH conjugated Synthetic peptide corresponding to Mouse GPR161 |
Isotype: | IgG |
Purity: | Affinity purification |
Predicted MW. | 60 kDa |
Observed MW. | 65 kDa |
Uniprot ID: | B2RPY5 |
Product Usage Information
Applications | Species | Dilution | Positive Sample |
WB | Mouse, Rat | 1: 500-1: 1000 | heart, brain |
Background
GPR161 (also known as RE2) is an orphan G protein-coupled receptor and plays important roles in the Hh pathway. In the absence of Hh signals, GPR161 localizes to primary cilia and keeps the downstream GLI transcription factors in their repressor forms . Ciliary localization of GPR161 requires TULP3 and the IFT-A complex. In presence of SHH, GPR161 is removed from primary cilia and is internalized into recycling endosomes, preventing its activity and allowing activation of the Shh signaling.
Images
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Western blot analysis of GPR161 (GB111421) at dilution of 1: 500 |
Storage
| Storage | Store at -20°C for one year. Avoid repeated freeze/thaw cycles. |
| Storage Buffer | PBS with 0.02%sodium azide,100 μg/ml BSA and 50% glycerol. |
