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| Reactivity: | H,M |
| Applications: | WB |
| Host Species: | Rabbit |
| Clonality: | Polyclonal |
| Full Name: | GRK2 rabbit polyclonal antibody |
Gene Name: | Beta-adrenergic receptor kinase 1 |
Synonyms: | Beta-ARK-1, G-protein-coupled receptor kinase 2, Grk2, Adrbk1 |
Immunogen: | Recombinant protein corresponding to Mouse GRK2 |
Isotype: | IgG |
Purity: | Affinity purification |
Predicted MW. | 80 kDa |
Observed MW. | 80 kDa |
Uniprot ID: | P25098, Q99MK8 |
Product Usage Information
Applications | Species | Dilution | Positive tissue |
WB | Human, Mouse | 1: 500-1: 1000 | spleen, lymph nodes |
Background
The product of this gene phosphorylates the beta-2-adrenergic receptor and appears to mediate agonist-specific desensitization observed at high agonist concentrations. This protein is an ubiquitous cytosolic enzyme that specifically phosphorylates the activated form of the beta-adrenergic and related G-protein-coupled receptors. Abnormal coupling of beta-adrenergic receptor to G protein is involved in the pathogenesis of the failing heart.
Images
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Western blot analysis of grk2 (GB111115) at dilution of 1: 500 |
Storage
| Storage | Store at -20°C for one year. Avoid repeated freeze/ thaw cycles. |
| Storage Buffer | PBS with 0.02% sodium azide, 100 μg/ml BSA and 50% glycerol. |
