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| Reactivity: | H |
| Applications: | WB |
| Host Species: | Rabbit |
| Clonality: | Polyclonal |
| Gene Name: | Beta-adrenergic receptor kinase 1 |
Synonyms: | Beta-ARK-1, G-protein-coupled receptor kinase 2, Grk2, Adrbk1 |
Immunogen: | KLH conjugated Synthetic peptide corresponding to Mouse GRK2 |
Uniprot ID: | Q99MK8 |
Isotype: | lgG |
Purity: | Affinity purification |
Predicted MW. / Observed MW. | 80 kDa / 80 kDa |
Product Usage Information
WB | Human | 1: 300-1: 400 | THP-1, jurkat |
Background
Specifically phosphorylates the agonist-occupied form of the beta-adrenergic and closely related receptors, probably inducing a desensitization of them (By similarity). Key regulator of LPAR1 signaling (By similarity). Competes with RALA for binding to LPAR1 thus affecting the signaling properties of the receptor (By similarity). Desensitizes LPAR1 and LPAR2 in a phosphorylation-independent manner (By similarity). Positively regulates ciliary smoothened (SMO)-dependent Hedgehog (Hh) signaling pathway by facilitating the trafficking of SMO into the cilium and the stimulation of SMO activity (By similarity). Inhibits relaxation of airway smooth muscle in response to blue light
Images
| WB analysis of ADRBK1 (GB115552). |
Storage
| Storage | Store at -20°C for one year. Avoid repeated freeze/thaw cycles. |
| Storage Buffer | PBS with 0.02%sodium azide,100 μg/ml BSA and 50% glycerol. |
