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Anti-GilZ / TilZ Rabbit pAb (100 μl)
| Reactivity: | M |
| Applications: | WB |
| Host Species: | Rabbit |
| Clonality: | Polyclonal |
| Full Name: | GILZ rabbit polyclonal |
Gene Name: | TSC22 domain family protein 3 |
Synonyms: | TSC22D3, DIP, DSIPI, GILZ, TSC-22R, hDIP, TSC22 domain family member 3 |
Immunogen: | KLH conjugated Synthetic peptide corresponding to Mouse GILZ |
Isotype: | IgG |
Purity: | Affinity purification |
Subcellular location: | |
Uniprot ID: |
Product Usage Information
Applications | Species | Dilution | Positive tissue |
IHC | Mouse, Rat | 1:1500-1:3000 | testis, brain, lung, kidney, ovary |
IF | Mouse, Rat | 1:800-1:1600 | testis, brain, lung, kidney, ovary |
Background
Protects T-cells from IL2 deprivation-induced apoptosis through the inhibition of FOXO3A transcriptional activity that leads to the down-regulation of the pro-apoptotic factor BCL2L11. In macrophages, plays a role in the anti-inflammatory and immunosuppressive effects of glucocorticoids and IL10. In T-cells, inhibits anti-CD3-induced NFKB1 nuclear translocation. In vitro, suppresses AP1 and NFKB1 DNA-binding activities (By similarity). Isoform 1 and isoform 4 inhibit myogenic differentiation and mediate anti-myogenic effects of glucocorticoids by binding and regulating MYOD1 and HDAC1 transcriptional activity resulting in reduced expression of MYOG.
Images
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Immunohistochemistry analysis of paraffin-embedded rat testis using GILZ (GB11303) at dilution of 1: 800 |
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Immunohistochemistry analysis of paraffin-embedded rat brain using GILZ (GB11303) at dilution of 1: 800 |
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Immunohistochemistry analysis of paraffin-embedded mouse lung using GILZ (GB11303) at dilution of 1: 800 |
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Immunohistochemistry analysis of paraffin-embedded mouse testis using GILZ(GB11303) at dilution of 1: 800 |
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Immunohistochemistry analysis of paraffin-embedded mouse ovary using GILZ(GB11303) at dilution of 1: 800 |
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Immunohistochemistry analysis of paraffin-embedded mouse kidney using GILZ(GB11303) at dilution of 1: 800 |
Storage
| Storage | Store at -20°C for one year. Avoid repeated freeze/ thaw cycles. |
| Storage Buffer | PBS with 0.02% sodium azide, 100 μg/ml BSA and 50% glycerol. |
