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Anti-Glucocorticoid Receptor Rabbit pAb (100 μl)
| Reactivity: | H |
| Applications: | WB |
| Host Species: | Rabbit |
| Clonality: | Polyclonal |
| Gene Name: | Glucocorticoid receptor |
Synonyms: | NR3C1, GCCR, GCR, GCRST, GR, GRL, nuclear receptor subfamily 3 group C member 1, Glucocorticoid Receptor |
Immunogen: | Recombinant protein corresponding to Mouse Glucocorticoid receptor |
Uniprot ID: | P06537 |
Isotype: | IgG |
Purity: | Affinity purification |
Subcellular location: | Cytoplasm, Nucleus, Mitochondrion |
Predicted MW. / Observed MW. | 91 kDa / 91 kDa |
Product Usage Information
WB | Human, Mouse, Rat | 1: 500-1: 1000 | heart, kidney |
IHC/IF | Mouse, Rat | 1: 1000-1: 3000 | liver, spleen |
Background
Function both as a transcription factor that binds to glucocorticoid response elements in the promoters of glucocorticoidresponsive genes to activate their transcription, and as a regulator of other transcription factors. This receptor is typically found in the cytoplasm, but upon ligand binding, is transported into the nucleus. It is involved in inflammatory responses, cellular proliferation, and differentiation in target tissues. Mutations in this gene are associated with generalizedglucocorticoid resistance. Alternative splicing of this gene results in transcript variants encoding either the same or different isoforms.
Images
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Western blot analysis of GR (GB11296) at dilution of 1: 1000 |
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Immunohistochemistry analysis of paraffin embedded mouse liver using GR (GB11296) at dilution of 1: 3000 |
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Immunohistochemistry analysis of paraffin embedded rat spleen using GR (GB11296) at dilution of 1: 1500 |
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Immunohistochemistry analysis of paraffin embedded rat liver using GR (GB11296) at dilution of 1: 1500 |
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Immunohistochemistry analysis of paraffin embedded mouse spleen using GR (GB11296) at dilution of 1: 1500 |
| Immunohistochemistry analysis of paraffin embedded mouse liver using GR (GB11296) at dilution of 1: 1500 |
| Immunofluorescent analysis of paraffin embedded rat liver using GR (GB11296) at dilution of 1: 1000 |
| Immunofluorescent analysis of paraffin embedded mouse spleen using GR (GB11296) at dilution of 1: 1000 |
| Immunofluorescent analysis of paraffin embedded mouse liver using GR (GB11296) at dilution of 1: 1000 |
Storage
| Storage | Store at -20°C for one year. Avoid repeated freeze/ thaw cycles. |
| Storage Buffer | PBS with 0.02% sodium azide, 100 μg/ml BSA and 50% glycerol. |
