Your shopping cart is empty!
| Reactivity: | H,M,R |
| Applications: | WB |
| Host Species: | Rabbit |
| Clonality: | Polyclonal |
| Full Name: | HDAC7 rabbit polyclonal antibody |
Gene Name: | Histone deacetylase 7 |
Synonyms: | HDAC7, HD7A, HDAC7A, HD7, histone deacetylase 7 |
Immunogen: | Recombinant protein corresponding to Mouse HDAC7 |
Isotype: | IgG |
Purity: | Affinity purification |
Predicted MW. | 101 kDa |
Observed MW. | 105 kDa |
Uniprot ID: |
Product Usage Information
Applications | Species | Dilution | Positive tissue |
WB | Human, Mouse, Rat | 1: 500-1: 1000 | lung, heart |
Background
Histones play a critical role in transcriptional regulation, cell cycle progression, and developmental events. Histone acetylation/deacetylation alters chromosome structure and affects transcription factor access to DNA. The production of HDAC7 gene has sequence homology to members of the histone deacetylase family. HDAC7 has both structural and functional similarity to HDACs 4, 5, and 9, as these four HDACs make up the Class IIa of HDACs in higher eukaryotes. Class IIa HDACs are phosphorylated by calcium/calmodulin dependent-kindase (CaMK) and protein kinase D (PKD) in response to kinase-dependent signaling. HDAC7 possesses little intrinsic deacetylase activity and therefore requires association with the class I HDAC, HDAC3 in order to suppress gene expression.
Images
 |
Western blot analysis of HDAC7 (GB11606) at dilution of 1: 500 |
Storage
| Storage | Store at -20°C for one year. Avoid repeated freeze/ thaw cycles. |
| Storage Buffer | PBS with 0.02% sodium azide, 100 μg/ml BSA and 50% glycerol. |
