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Anti-HIF-1 alpha Rabbit pAb (100 μl)
| Reactivity: | H |
| Applications: | WB |
| Host Species: | Rabbit |
| Clonality: | Polyclonal |
| Full Name: | HIF-1 alpha rabbit polyclonal |
Protein full name | Hypoxia-inducible factor 1-alpha |
Synonyms: | HIF1A, HIF-1-alpha, HIF-1A, HIF-1alpha, HIF1, HIF1-ALPHA, MOP1, PASD8, bHLHe78, hypoxia inducible factor 1 alpha subunit |
Immunogen: | KLH conjugated Synthetic peptide corresponding to Mouse HIF-1α |
Isotype: | IgG |
Predicted MW. | 120 kDa |
Observed MW. | 120 kDa |
Purity: | Affinity purification |
Uniprot ID: |
Images
Applications | Species | Dilution | Positive Tissue |
WB | Human | 1: 500-1: 1000 | anaerobic Hela, anaerobic A549 |
Background
Functions as a master transcriptional regulator of the adaptive response to hypoxia. Under hypoxic conditions, activates the transcription of over 40 genes, including erythropoietin, glucose transporters, glycolytic enzymes, vascular endothelial growth factor, HILPDA, and other genes whose protein products increase oxygen delivery or facilitate metabolic adaptation to hypoxia. Plays an essential role in embryonic vascularization, tumor angiogenesis and pathophysiology of ischemic disease.
Images
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Western blot analysis of HIF-1 alpha (111339) at dilution of 1: 1000. Lane 1: Hela cell lysate (normoxia cultivation) Lane 2: Hela cell lysate (anaerobic cultivation) Lane 3: A549 cell lysate (normoxia cultivation) Lane 4: A549 cell lysate (anaerobic cultivation) |
Storage
| Storage | Store at -20°C for one year. Avoid repeated freeze/ thaw cycles. |
| Storage Buffer | PBS with 0.02% sodium azide, 100 μg/ml BSA and 50% glycerol. |
