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| Reactivity: | H |
| Applications: | WB |
| Host Species: | Rabbit |
| Clonality: | Polyclonal |
| Full Name: | HIF3A rabbit polyclonal |
Gene Name: | Hypoxia-inducible factor 3-alpha |
Synonyms: | HIF 3 alpha, HIF-3 Alpha, HIF 3A4, HIF3 alpha, HIF3A, HIF-3A, Hypoxia Inducible Factor 3 alpha, Hypoxia inducible factor 3 alpha subunit, Inhibitory PAS domain protein, IPAS, MOP7, PASD7 |
Immunogen: | KLH conjugated Synthetic peptide corresponding to Mouse HIF3A |
Isotype: | IgG |
Purity: | Affinity purification |
Predicted MW. | 73 kDa |
Observed MW. | 73 kDa |
Uniprot ID: |
Product Usage Information
Applications | Species | Dilution | Positive tissue |
WB | Human | 1: 500-1: 1000 | MCF7, A431, HUVEC |
Background
Hypoxia-inducible factor (HIF) is one of the most important factors in the cellular response to hypoxia, transcriptionally activating genes encoding proteins that mediate adaptive responses to reduced oxygen availability. HIF is a heterodimer consisting of one of three subunits, HIF1 alpha, HIF2 alpha, or HIF3 alpha. HIF target genes play critical roles in metabolism, angiogenesis, cell proliferation and cell survival. HIF3 alpha protein is one of several alpha/beta-subunit heterodimeric transcription factors that regulate many adaptive responses to low oxygen tension (hypoxia). The alpha 3 subunit lacks the transactivation domain found in factors containing either the alpha 1 or alpha 2 subunits. HIF3 alpha may be a marker for tumor growth and angiogenesis
Images
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Western blot analysis of Hif3a (GB11844) at dilution of 1: 1000 |
Storage
| Storage | Store at -20°C for one year. Avoid repeated freeze/ thaw cycles. |
| Storage Buffer | PBS with 0.02% sodium azide, 100 μg/ml BSA and 50% glycerol. |
